CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | BROWNISH-YELLOW CRYSTALS |
|---|---|
| Boiling Point | 442.3 ºC |
| Melting Point | 139 |
| Solubility | Brick-red microcrystals, slight violet luster; aq soln are yellow to brick-red slightly sol in cold water, 1 part in 300; sol in boiling water, 1 part in 20; 1 part is sol in 100 parts glycerol usp; slightly sol in alcohol, lanolin; sol in ethylene and propylene glycols, acetic acid; insol in acetone, benzene, chloroform, ether, toluene /Phenazopyridine hydrochloride/ |
| LogP | 2.62 |
| LogS | 3.83 |
| Stability/Shelf Life | WILL PRECIPITATE OUT OF 2% SOLN AT 25 °C AFTER ABOUT 2 DAYS, & OUT OF 1% SOLN ONLY AFTER MONTHS /PHENAZOPYRIDINE HYDROCHLORIDE/ |
| Decomposition | When heated todecomposition it emits toxic fumes of /nitrogen oxides/. |
| pH | AQ SOLN ARE SLIGHTLY ACID |
| Dissociation Constants | 5.05 |
| Kovats Retention Index | 2345 2280 2290 2345 2346 |
| Other Experimental Properties | Slightly bitter taste /Phenazopyridine hydrochloride/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 213.24 g/mol |
|---|---|
| XLogP3 | 1.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 213.10144537 g/mol |
| Monoisotopic Mass | 213.10144537 g/mol |
| Topological Polar Surface Area | 89.6 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 237 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Phenazopyridine is a diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. It has a role as a local anaesthetic, a non-narcotic analgesic, a carcinogenic agent and an anticoronaviral agent. It is a diaminopyridine and a monoazo compound. It is a conjugate base of a phenazopyridine(1+).