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90103-92-7

90103-92-7 structural image
Product Name: Zabiciprilat
Formula: C21H28N2O5
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COMPUTED DESCRIPTORS

Molecular Weight 388.5 g/mol
XLogP3 0.7
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 8
Exact Mass 388.19982200 g/mol
Monoisotopic Mass 388.19982200 g/mol
Topological Polar Surface Area 107 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 581
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Zabiciprilat is a non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Zabiciprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zabiciprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.