9004-07-3
Product Name:
α-Chymotrypsin
Formula:
N/A
Synonyms:
CLCR;CTRC;CTRC_HUMAN;ELA 4;Elastase 4
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | WHITE TO YELLOWISH WHITE; CRYSTALLINE OR AMORPHOUS POWDER |
|---|---|
| Odor | ODORLESS |
| Solubility | 100000 USP UNITS SOL IN 10 ML WATER, 10 ML SALINE TS |
| Stability/Shelf Life | LYOPHILIZED ENZYME IS STABLE FOR YEARS @ 4 °C. |
| Other Experimental Properties | FREEZING INACTIVATES ENZYME; MOST ACTIVE @ PH 8 TO 9; ACTIVITY ENHANCED BY PRESENCE OF CALCIUM IONS |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 499.5 g/mol |
|---|---|
| XLogP3 | 0.4 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 12 |
| Exact Mass | 499.17031277 g/mol |
| Monoisotopic Mass | 499.17031277 g/mol |
| Topological Polar Surface Area | 200 Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 801 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. Like most proteolytic enzymes, chymotrypsin is activated from its inactive zymogen precursor, chymotrypsinogen, in presence of [DB11237]. Chymotrypsin is the most abundant pancreatic proteases that represent up to 10-20% of the total protein synthesized by the exocrine pancreas. Chymotrypsin contains both the catalytic triad and oxyanion hole, and the tertiary structure of chymotrypsin is similar to [DB11237].