CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | White powder |
|---|---|
| Solubility | Easily soluble in cold water, hot water. |
| Stability/Shelf Life | Solutions are stable to heat. an aqueous solution buffered to pH 7.5 may be put in a boiling water bath for at least 120 min. In 0.10 molar HCl an 0.2% solution retains its biological potency when kept at 100 °C for 60 min, but in 0.10 molar NaOH the activity is lost within 30 min. At 60 °C at 0.2% solution at pH 10.8 maintains its potency for 60 min. In general the substance is more stable in acid solution. |
| Decomposition | When heated to decomposition, material emits toxic fumes of nitrogen oxides and sulfur oxides. |
| Other Experimental Properties | Solutions are stable to heat. In general, it is more stable in acid solution. |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H332:Acute toxicity,inhalation H334:Sensitisation, respiratory H361:Reproductive toxicity |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
COMPUTED DESCRIPTORS
| Molecular Weight | 4541 g/mol |
|---|---|
| XLogP3 | -19.7 |
| Hydrogen Bond Donor Count | 63 |
| Hydrogen Bond Acceptor Count | 68 |
| Rotatable Bond Count | 148 |
| Exact Mass | 4540.2660828 g/mol |
| Monoisotopic Mass | 4538.2593732 g/mol |
| Topological Polar Surface Area | 1860 Ų |
| Heavy Atom Count | 322 |
| Formal Charge | 0 |
| Complexity | 11200 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 36 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency. It has a role as a diagnostic agent. It is a polypeptide, a peptide hormone and a biomacromolecule.