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873054-44-5

873054-44-5 structural image
Product Name: Ivacaftor
Formula: C24H28N2O3
Synonyms: CFTR Potentiator, VX-770 - CAS 873054-44-5 - Calbiochem;N-(5-Hydroxy-2,4- bis(2-methyl-2-propanyl)phenyl]-4-oxo-1,4-dihydro-3-quinolinecarboxamide, Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, VX 770, Ivacaftor, Kalydeco;N-(5-Hydroxy-2,4-bis(2-methyl-2-propanyl)phenyl]-4-oxo-1,4-dihydro-3-quinolinecarboxamide, Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, VX 770, Ivacaftor, Kalydeco
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Boiling Point 550.4
Melting Point 212-215
Solubility low (<0.05 µg/mL)
LogP 3.13
Dissociation Constants 11.08, 1.5

COMPUTED DESCRIPTORS

Molecular Weight 392.5 g/mol
XLogP3 5.6
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 4
Exact Mass 392.20999276 g/mol
Monoisotopic Mass 392.20999276 g/mol
Topological Polar Surface Area 78.4 Ų
Heavy Atom Count 29
Formal Charge 0
Complexity 671
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Ivacaftor is an aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis. It has a role as a CFTR potentiator and an orphan drug. It is a quinolone, a member of phenols, an aromatic amide and a monocarboxylic acid amide.

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