COMPUTED DESCRIPTORS
| Molecular Weight | 353.4 g/mol |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 7 |
| Exact Mass | 353.18517499 g/mol |
| Monoisotopic Mass | 353.18517499 g/mol |
| Topological Polar Surface Area | 101 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 405 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Epiroprim is a trimethoprim analogue and selective inhibitor of microbial dihydrofolate reductase, with antibacterial activity. Epiroprim inhibits the bacterial enzyme dihydrofolate reductase, selectively blocking the conversion of dihydrofolic acid to tetrahydrofolic acid. By depleting folate molecules, epiroprim inhibits bacterial nucleic acid synthesis.