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71-68-1

71-68-1 structural image
Product Name: Hydromorphone hydrochloride
Formula: C17H20ClNO3
Synonyms: (5α)-4,5-Epoxy-3-hydroxy-17-methyl-morphinan-6-one hydrochloride;Hydromorphone HCl
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SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H336:Specific target organ toxicity,single exposure; Narcotic effects

COMPUTED DESCRIPTORS

Molecular Weight 321.8 g/mol
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 0
Exact Mass 321.1131712 g/mol
Monoisotopic Mass 321.1131712 g/mol
Topological Polar Surface Area 49.8 Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 494
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 2
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Hydromorphone Hydrochloride is the hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.

RELATED SUPPLIERS

Ralington Pharma

1Y
product:71-68-1 Hydromorphone hydrochloride 98%
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