68278-23-9
Product Name:
Eflornithine hydrochloride
Formula:
C6H13ClF2N2O2
Synonyms:
2-(Difluoromethyl)-DL -ornithine monohydrochloride monohydrate;Eflornithin monohydrochloride monohydrate
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COMPUTED DESCRIPTORS
| Molecular Weight | 218.63 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 218.0633617 g/mol |
| Monoisotopic Mass | 218.0633617 g/mol |
| Topological Polar Surface Area | 89.3 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 166 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Eflornithine Hydrochloride is the hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. (NCI04)
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