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67337-44-4

67337-44-4 structural image
Product Name: METHOXYMETHYL 7-[4-(4-HYDROXYPHENYL)-2,2-DIMETHYL-5-OXO-IMIDAZOLIDIN-1-YL]-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLATE
Formula: C21H27N3O6S
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COMPUTED DESCRIPTORS

Molecular Weight 449.5 g/mol
XLogP3 1.6
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 6
Exact Mass 449.16205676 g/mol
Monoisotopic Mass 449.16205676 g/mol
Topological Polar Surface Area 134 Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 766
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Sarmoxicillin is an amoxicillin prodrug and the methoxymethyl ester of hetamoxicillin with antibacterial activity. Sarmoxicillin is hydrolyzed in vivo by esterases to its active metabolite amoxicillin. Amoxicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.