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640281-90-9

640281-90-9 structural image
Product Name: Valopicitabine
Formula: C15H24N4O6
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COMPUTED DESCRIPTORS

Molecular Weight 356.37 g/mol
XLogP3 -2
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 6
Exact Mass 356.16958450 g/mol
Monoisotopic Mass 356.16958450 g/mol
Topological Polar Surface Area 161 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 607
Isotope Atom Count 0
Defined Atom Stereocenter Count 5
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

The 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity. Upon administration, valopicitabine is converted into 2'-C-methylcytidine; upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication. [from NCI]