COMPUTED DESCRIPTORS
| Molecular Weight | 367.2 g/mol |
|---|---|
| XLogP3 | 3.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 6 |
| Exact Mass | 366.0537978 g/mol |
| Monoisotopic Mass | 366.0537978 g/mol |
| Topological Polar Surface Area | 45.5 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 472 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Parconazole is a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, parconazole, like other azole antifungals, most likely inhibits the cytochrome P450 dependent 14 alpha demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of the fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, parconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.