6066-82-6
Product Name:
N-Hydroxysuccinimide
Formula:
C4H5NO3
Synonyms:
1-Hydroxy-2,5-pyrrolidinedione;HOSu;NHS;N-Hydroxysuccinimide;N-Hydroxysuccinimide, NHS
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | White odorless solid; [GE Healthcare MSDS] |
|---|---|
| Chemical Classes | Nitrogen Compounds -> Succinimides |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. |
COMPUTED DESCRIPTORS
| Molecular Weight | 115.09 g/mol |
|---|---|
| XLogP3 | -1.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 0 |
| Exact Mass | 115.026943022 g/mol |
| Monoisotopic Mass | 115.026943022 g/mol |
| Topological Polar Surface Area | 57.6 Ų |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
| Complexity | 126 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
Description
N-Hydroxysuccinimide (NHS ) is a chemical modification reagent used to convert carboxyl groups into amine-reactive NHS esters for use in biocoupling, cross-linking, labelling, and immobilisation methods.