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59467-70-8

59467-70-8 structural image
Product Name: Midazolam
Formula: C18H13ClFN3
Synonyms: 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;Midazolam-d4 maleate solution
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Color/Form Colorless crystals from ether/methylene chloride/ hexane
Boiling Point 497
Melting Point 161-164
Solubility soluble
Stability/Shelf Life Midazolam hydrochloride is reportedly stable at a pH of 3-3.6.
Decomposition When heated to decomposition it emits toxic fumes of /hydrogen fluoride, hydrogen chloride and nitrogen oxides/.
Dissociation Constants pKa = 5.5 (calc)
Collision Cross Section 172.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Kovats Retention Index 2559 2559 2620 2580 2604.9
Other Experimental Properties Soluble in aqueous solutions /Midazolam hydrochloride/

SAFETY INFORMATION

Signal word Danger
Pictogram(s)

Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405:Store locked up.
P501:Dispose of contents/container to..…

COMPUTED DESCRIPTORS

Molecular Weight 325.8 g/mol
XLogP3 2.5
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 1
Exact Mass 325.0782033 g/mol
Monoisotopic Mass 325.0782033 g/mol
Topological Polar Surface Area 30.2 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 471
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Midazolam is an imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively. It has a role as a GABAA receptor agonist, an anticonvulsant, an anxiolytic drug, an apoptosis inducer, an antineoplastic agent, a muscle relaxant, a sedative, a general anaesthetic and a central nervous system depressant. It is an organochlorine compound, an imidazobenzodiazepine and a member of monofluorobenzenes.