CHEMICAL AND PHYSICAL PROPERTIES
Color/Form | YELLOW, CRYSTALLINE POWDER |
---|---|
Melting Point | 201 °C |
Solubility | 50 mg/mL |
LogP | 0.63 |
Dissociation Constants | 3.09 |
Collision Cross Section | 197.4 Ų [M+H]+ [CCS Type: TW] |
Other Experimental Properties | CHARS WITHOUT MELTING @ ABOUT 201 °C. /DOXYCYCLINE HYDROCHLORIDE/ |
COMPUTED DESCRIPTORS
Molecular Weight | 444.4 g/mol |
---|---|
XLogP3 | -0.7 |
Hydrogen Bond Donor Count | 6 |
Hydrogen Bond Acceptor Count | 9 |
Rotatable Bond Count | 2 |
Exact Mass | 444.15326573 g/mol |
Monoisotopic Mass | 444.15326573 g/mol |
Topological Polar Surface Area | 182 Ų |
Heavy Atom Count | 32 |
Formal Charge | 0 |
Complexity | 956 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 6 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Doxycycline is tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis. It has a role as an antibacterial drug, an antimalarial, a geroprotector, an anti-inflammatory agent and an immunomodulator.