79-57-2
Product Name:
Oxytetracycline
Formula:
C22H24N2O9
Synonyms:
OTC;Oxytetracycline dihydrate
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Light yellow to tan solid; [HSDB] Pale yellow to tan crystalline powder; [Acros Organics MSDS] |
|---|---|
| Color/Form | Light-yellow crystals or needles from aqueous MeOH |
| Melting Point | 184.5 °C |
| Solubility | 47 [ug/mL] (The mean of the results at pH 7.4) |
| Density | 1.634 at 20 °C |
| LogP | -0.9 |
| LogS | -3.14 |
| Stability/Shelf Life | STABLE IN AIR, BUT EXPOSURE TO STRONG SUNLIGHT CAUSES IT TO DARKEN. /OXYTETRACYCLINE DIHYDRATE/ |
| Dissociation Constants | 3.27 (at 25 °C) |
| Collision Cross Section | 203.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
| Other Experimental Properties | SATURATED SOLN PH IS ABOUT 6.5; SPECIFIC OPTICAL ROTATION -207 TO -216 DEG (100 MG IN 10 ML 0.1 NORMAL HYDROCHLORIC ACID); PALE YELLOW TO TAN CRYSTALLINE POWDER /OXYTETRACYCLINE DIHYDRATE/ |
| Chemical Classes | Other Uses -> Pharmaceuticals |
SAFETY INFORMATION
| Signal word | Warning |
|---|---|
| Pictogram(s) |
 Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P308+P313:IF exposed or concerned: Get medical advice/attention. |
COMPUTED DESCRIPTORS
| Molecular Weight | 460.4 g/mol |
|---|---|
| XLogP3 | -1.6 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 2 |
| Exact Mass | 460.14818035 g/mol |
| Monoisotopic Mass | 460.14818035 g/mol |
| Topological Polar Surface Area | 202 Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 1000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 6 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Oxytetracycline is a tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae. It has a role as an antibacterial drug, a protein synthesis inhibitor, an antimicrobial agent, an anti-inflammatory drug and a bacterial metabolite. It is a tautomer of an oxytetracycline zwitterion.