CHEMICAL AND PHYSICAL PROPERTIES
Kovats Retention Index | 2169 |
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COMPUTED DESCRIPTORS
Molecular Weight | 291.4 g/mol |
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XLogP3 | 4.7 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 7 |
Exact Mass | 291.219829168 g/mol |
Monoisotopic Mass | 291.219829168 g/mol |
Topological Polar Surface Area | 41.5 Ų |
Heavy Atom Count | 21 |
Formal Charge | 0 |
Complexity | 276 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Exaprolol is a lipophilic derivative of the adrenergic blocking agent propranolol with sympatholytic activity. Exaprolol competitively binds to and blocks beta-adrenergic receptors in the heart and vascular smooth muscle, thereby causing negative chronotropic and inotropic effects leading to a reduction in cardiac output.