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53714-56-0

53714-56-0 structural image
Product Name: Leuprorelin
Formula: C59H84N16O12
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CHEMICAL AND PHYSICAL PROPERTIES

Color/Form Fluffy solid
Melting Point 150-155
Optical Rotation Specific optical rotation: -31.7 deg @ 25 °C/D (c=1 in 1% HOAc)
Dissociation Constants 9.6

SAFETY INFORMATION

Signal word Danger
Pictogram(s)

Health Hazard
GHS08
GHS Hazard Statements H360:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.

COMPUTED DESCRIPTORS

Molecular Weight 1209.4 g/mol
XLogP3 0.7
Hydrogen Bond Donor Count 15
Hydrogen Bond Acceptor Count 14
Rotatable Bond Count 32
Exact Mass 1208.64546218 g/mol
Monoisotopic Mass 1208.64546218 g/mol
Topological Polar Surface Area 432 Ų
Heavy Atom Count 87
Formal Charge 0
Complexity 2390
Isotope Atom Count 0
Defined Atom Stereocenter Count 9
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Leuprolide is an oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. It has a role as an antineoplastic agent, a gonadotropin releasing hormone agonist and an anti-estrogen.

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AKASH PHARMA EXPORTS

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All suppliers(4)