477-30-5
Product Name:
DEMECOLCINE
Formula:
C21H25NO5
Synonyms:
Colcemid - CAS 477-30-5 - Calbiochem;Colcemid solution;Demecolcine;N-Deacetyl-N-methylcolchicine;N-Deacetyl-N-methylcolchicine solution
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Pale yellow solid; [Merck Index] Light yellow crystalline solid; [Sigma-Aldrich MSDS] |
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Chemical Classes | Other Uses -> Biochemical Research |
SAFETY INFORMATION
Signal word | Danger |
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Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H300:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
COMPUTED DESCRIPTORS
Molecular Weight | 371.4 g/mol |
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XLogP3 | 1.4 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 6 |
Rotatable Bond Count | 5 |
Exact Mass | 371.17327290 g/mol |
Monoisotopic Mass | 371.17327290 g/mol |
Topological Polar Surface Area | 66 Ų |
Heavy Atom Count | 27 |
Formal Charge | 0 |
Complexity | 653 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 1 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
(-)-demecolcine is a secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is an alkaloid and a secondary amino compound.