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477-30-5

477-30-5 structural image
Product Name: DEMECOLCINE
Formula: C21H25NO5
Synonyms: Colcemid - CAS 477-30-5 - Calbiochem;Colcemid solution;Demecolcine;N-Deacetyl-N-methylcolchicine;N-Deacetyl-N-methylcolchicine solution
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Pale yellow solid; [Merck Index] Light yellow crystalline solid; [Sigma-Aldrich MSDS]
Chemical Classes Other Uses -> Biochemical Research

SAFETY INFORMATION

Signal word Danger
Pictogram(s)

Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H300:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

COMPUTED DESCRIPTORS

Molecular Weight 371.4 g/mol
XLogP3 1.4
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 5
Exact Mass 371.17327290 g/mol
Monoisotopic Mass 371.17327290 g/mol
Topological Polar Surface Area 66 Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 653
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

(-)-demecolcine is a secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is an alkaloid and a secondary amino compound.