CHEMICAL AND PHYSICAL PROPERTIES
| Color/Form | Crystals from petroleum ether |
|---|---|
| Melting Point | 75.5 °C |
| Solubility | 3.32 mg/L (at 25 °C) |
| LogP | 4.18 |
| Stability/Shelf Life | ... Stable in solution at pH 2 to 3.5. /Propoxyphene hydrochloride/ |
| Optical Rotation | Specific optical rotation: +67.3 deg at 25 °C/D (chloroform, 0.6%) |
| Decomposition | When heated to decomposition it emits toxic fumes of /Nitrogen oxides/. . |
| Dissociation Constants | 9.06 |
| Collision Cross Section | 180.7 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
| Kovats Retention Index | 2192 2181 2178 2181 2178 2165 2190 2180 2183 2186 2203 2229 2210 2180 2180 2188 2171.1 2151 2182.8 2182.8 2165 2178 2179 2180 2181 2181 2181 2181 2180 2210 2188 2190 2190 |
| Other Experimental Properties | Bitter crystals from methanol plus ethyl acetate; sol in water, alcohol, acetone, chloroform; practically insol in benzene, ether; mp: 163-168.5 °C; specific optical rotation: +59.8 deg at 25 °C/D (water, 0.6%) /Propoxyphene hydrochloride/ |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P235:Store in a well-ventilated place. Keep cool. |
COMPUTED DESCRIPTORS
| Molecular Weight | 339.5 g/mol |
|---|---|
| XLogP3 | 4.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 9 |
| Exact Mass | 339.219829168 g/mol |
| Monoisotopic Mass | 339.219829168 g/mol |
| Topological Polar Surface Area | 29.5 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 397 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Dextropropoxyphene is the (1S,2R)-(+)-diastereoisomer of propoxyphene. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It is an enantiomer of a levopropoxyphene.