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4428-95-9

4428-95-9 structural image
Product Name: Foscarnet
Formula: CH3O5P
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 88.06 °C
Solubility Complete
LogP -2.1
Other Experimental Properties Hexahydrate, mp >250 °C/Foscarnet sodium/

COMPUTED DESCRIPTORS

Molecular Weight 126.01 g/mol
XLogP3 -2
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 1
Exact Mass 125.97181019 g/mol
Monoisotopic Mass 125.97181019 g/mol
Topological Polar Surface Area 94.8 Ų
Heavy Atom Count 7
Formal Charge 0
Complexity 120
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Phosphonoformic acid is phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. It has a role as an antiviral drug, a sodium-dependent Pi-transporter inhibitor, a HIV-1 reverse transcriptase inhibitor and a geroprotector. It is a one-carbon compound, a member of phosphonic acids and a carboxylic acid. It is functionally related to a phosphonic acid and a formic acid. It is a conjugate acid of a phosphonatoformate and a phosphonoformate(2-).