42924-53-8
Product Name:
Nabumetone
Formula:
C15H16O2
Synonyms:
4-(6-Methoxy-2-naphthyl)-2-butanone;Nabumetone
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CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
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Melting Point | 78-82 |
Solubility | Practically insoluble |
LogP | 2400 |
Collision Cross Section | 148 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
Kovats Retention Index | 2103 |
SAFETY INFORMATION
Signal word | Warning |
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Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H303:Acute toxicity,oral |
Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P403:Store in a well-ventilated place. |
COMPUTED DESCRIPTORS
Molecular Weight | 228.29 g/mol |
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XLogP3 | 3.1 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 2 |
Rotatable Bond Count | 4 |
Exact Mass | 228.115029749 g/mol |
Monoisotopic Mass | 228.115029749 g/mol |
Topological Polar Surface Area | 26.3 Ų |
Heavy Atom Count | 17 |
Formal Charge | 0 |
Complexity | 262 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Nabumetone is a methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a cyclooxygenase 2 inhibitor and a prodrug. It is a methoxynaphthalene and a methyl ketone.
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