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37691-11-5

37691-11-5 structural image
Product Name: ANTIPAIN HYDROCHLORIDE DIHYDRATE
Formula: C27H44N10O6
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SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

COMPUTED DESCRIPTORS

Molecular Weight 604.7 g/mol
XLogP3 -2.7
Hydrogen Bond Donor Count 9
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 19
Exact Mass 604.34452916 g/mol
Monoisotopic Mass 604.34452916 g/mol
Topological Polar Surface Area 283 Ų
Heavy Atom Count 43
Formal Charge 0
Complexity 975
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Antipain is a serine/cysteine protease inhibitor originally isolated from various strains of actinomycetes. Early studies investigated the potential for antipain to alter DNA damage and chromosomal aberrations in irradiated cells or those treated with chemical mutagens such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Antipain was used in 2010 to obtain a crystal structure of the Leishmania major oligopeptidase B (OPB), a serine protease that serves as a virulence factor in trypanosomatids. The binding of antipain to OPB has been used in molecular dynamic studies to identify other OPB inhibitors with more favourable pharmacodynamic and pharmacokinetic properties for potential development as anti-trypanosomatid drugs.