34552-83-5
Product Name:
Loperamide hydrochloride
Formula:
C29H34Cl2N2O2
Synonyms:
µ-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium;4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride;Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem;LPM
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CHEMICAL AND PHYSICAL PROPERTIES
Solubility | >77 [ug/mL] (The mean of the results at pH 7.4) |
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Collision Cross Section | 219.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
SAFETY INFORMATION
Signal word | Danger |
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Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
COMPUTED DESCRIPTORS
Molecular Weight | 513.5 g/mol |
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Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 7 |
Exact Mass | 512.1997337 g/mol |
Monoisotopic Mass | 512.1997337 g/mol |
Topological Polar Surface Area | 43.8 Ų |
Heavy Atom Count | 35 |
Formal Charge | 0 |
Complexity | 623 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 2 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Loperamide hydrochloride is a hydrochloride obtained by combining loperamide with one equivalent of hydrochloric acid. Used for treatment of diarrhoea resulting from gastroenteritis or inflammatory bowel disease. It has a role as a mu-opioid receptor agonist, an antidiarrhoeal drug and an anticoronaviral agent. It contains a loperamide(1+).
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