34552-83-5
Product Name:
Loperamide hydrochloride
Formula:
C29H34Cl2N2O2
Synonyms:
µ-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium;4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride;Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem;LPM
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CHEMICAL AND PHYSICAL PROPERTIES
| Solubility | >77 [ug/mL] (The mean of the results at pH 7.4) |
|---|---|
| Collision Cross Section | 219.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
COMPUTED DESCRIPTORS
| Molecular Weight | 513.5 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 7 |
| Exact Mass | 512.1997337 g/mol |
| Monoisotopic Mass | 512.1997337 g/mol |
| Topological Polar Surface Area | 43.8 Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 623 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Loperamide hydrochloride is a hydrochloride obtained by combining loperamide with one equivalent of hydrochloric acid. Used for treatment of diarrhoea resulting from gastroenteritis or inflammatory bowel disease. It has a role as a mu-opioid receptor agonist, an antidiarrhoeal drug and an anticoronaviral agent. It contains a loperamide(1+).
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