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31356-94-2

31356-94-2 structural image
Product Name: 8-BR-CGMP
Formula: C10H11BrN5O7P
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COMPUTED DESCRIPTORS

Molecular Weight 424.10 g/mol
XLogP3 -2.4
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 1
Exact Mass 422.95795 g/mol
Monoisotopic Mass 422.95795 g/mol
Topological Polar Surface Area 171 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 651
Isotope Atom Count 0
Defined Atom Stereocenter Count 4
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

8-bromo-3',5'-cyclic GMP is a 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. It has a role as a muscle relaxant and a protein kinase G agonist. It is a 3',5'-cyclic purine nucleotide and an organobromine compound. It is functionally related to a 3',5'-cyclic GMP.