299-42-3
Product Name:
Ephedrine
Formula:
C10H15NO
Synonyms:
(−)-Ephedrine;(1R,2S)-(−)-α-(1-Methylaminoethyl)benzyl alcohol;(1R,2S)-(−)-2-Methylamino-1-phenyl-1-propanol;L -α-(1-Methylaminoethyl)benzyl alcohol
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | Waxy solid, crystals or granules |
| Boiling Point | 255 °C |
| Melting Point | 34 °C |
| Solubility | 63600 mg/L (at 30 °C) |
| Density | 1.0085 g/cu cm at 22 °C |
| LogP | 1.13 |
| Stability/Shelf Life | GRADUALLY DECOMP ON EXPOSURE TO LIGHT |
| Optical Rotation | Mol wt: 201.69. Fine, white, colorless crystals or powder, affected by light, mp 217-220 °C. Odorless. Specific optical rotation: -33 to -35.5 deg ar 25 °C/D ( c = 5). Freely soluble in water, soluble in alcohol. Practically insoluble in ether. /Ephedrine hydrochloride/ |
| Decomposition | When heated to decomposition it emits toxic fumes of /nitrogen oxides/ |
| pH | 10.8 aqueous solution (1 in 200) |
| Dissociation Constants | 9.61 |
| Collision Cross Section | 138.2 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated] |
| Kovats Retention Index | 1365 1376 1330 1350 1350 1350 1336 1370 1388 1337 1350 1370 1360 1365 1350 1363 1363 1352.4 1365.1 1365.8 1350 1346 1346 1348 1350 1350 1350 1350 1351 1352 1357 1358 1355 1363 1350 1370 1363 1370 1370 |
| Other Experimental Properties | Unctuous to touch ... hygroscopic, gradually decomposes on exposure to light |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H314:Skin corrosion/irritation H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
| Molecular Weight | 165.23 g/mol |
|---|---|
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 3 |
| Exact Mass | 165.115364102 g/mol |
| Monoisotopic Mass | 165.115364102 g/mol |
| Topological Polar Surface Area | 32.3 Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 121 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
(-)-ephedrine is a phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. It has a role as a nasal decongestant, a sympathomimetic agent, a vasoconstrictor agent, a xenobiotic, an environmental contaminant, a plant metabolite and a bacterial metabolite. It is a member of phenylethanolamines and a phenethylamine alkaloid. It is a conjugate base of a (-)-ephedrinium.