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297730-17-7

297730-17-7 structural image
Product Name: AVN-944
Formula: C25H27N5O5
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COMPUTED DESCRIPTORS

Molecular Weight 477.5 g/mol
XLogP3 3.1
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 10
Exact Mass 477.20121898 g/mol
Monoisotopic Mass 477.20121898 g/mol
Topological Polar Surface Area 139 Ų
Heavy Atom Count 35
Formal Charge 0
Complexity 743
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

AVN944 is a biotech drug that demonstrated a statistically meaningful impact on IMPDH and other proteins that are critical to activities in cancer cells, including nucleotide biosynthesis, energy and metabolism, DNA replication, apoptosis and cell cycle control. AVN944 has been associated with cancer cell death in clinical trials. It is being investigated for the treatment of patients with advanced hematologic malignancies.