CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid; [Merck Index] Faintly beige powder; [MSDSonline] |
|---|---|
| Color/Form | NEEDLES FROM METHANOL |
| Melting Point | 254-255 °C |
| Optical Rotation | SPECIFIC OPTICAL ROTATION: +191 DEG @ 20 °C/D; MAX ABSORPTION: 302 NM |
| Chemical Classes | Biological Agents -> Mushroom Toxins |
SAFETY INFORMATION
| Signal word | Danger |
|---|---|
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H300:Acute toxicity,oral H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P314:Get medical advice/attention if you feel unwell. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. |
COMPUTED DESCRIPTORS
| Molecular Weight | 919.0 g/mol |
|---|---|
| XLogP3 | -4.4 |
| Hydrogen Bond Donor Count | 13 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 7 |
| Exact Mass | 918.35416761 g/mol |
| Monoisotopic Mass | 918.35416761 g/mol |
| Topological Polar Surface Area | 400 Ų |
| Heavy Atom Count | 64 |
| Formal Charge | 0 |
| Complexity | 1840 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 11 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
alpha-Amanitin or α-amanitin is a cyclic peptide of eight amino acids. It is possibly the most deadly of all the amatoxins, toxins found in several members of the Amanita genus of mushrooms, one being the Death cap (Amanita phalloides) as well as the Destroying angel, a complex of similar species, principally A. virosa and A. bisporigera. It is also found in the mushrooms Galerina marginata and Conocybe filaris. (L993)