182431-12-5
Product Name:
Lomitapide
Formula:
C39H37F6N3O2
Synonyms:
AEGR-733;BMS-201038;N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]2-yl]carbonyl]amino]-1-piperidinyl]butyl]9H-fluoren-9-carboxamde
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Stability/Shelf Life | Stable if stored as directed; avoid strong oxidizing agents. /Lomitapide mesylate/[Selleck Chemicals; Material Safety Data Sheet: N-(2,2,2-trifluorethyl)-9-[4-[4-[[[4'-(trifluoromethyl) |
|---|---|
| Decomposition | Thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides. /Lomitapide mesylate/[Selleck Chemicals; Material Safety Data Sheet: N-(2,2,2-trifluorethyl)-9-[4-[4-[[[4'-(trifluoromethyl) |
| Other Experimental Properties | White to off-white powder; slightly soluble in aqueous solutions of pH 2 to 5; freely soluble in acetone, ethanol, methanol; soluble in 2-butanol, methylene chloride, acetonitrile; sparingly soluble in 1-octanol, 2-propanol; slightly soluble in ethyl acetate; insoluble in heptane /Lomitapide mesylate/ |
COMPUTED DESCRIPTORS
| Molecular Weight | 693.7 g/mol |
|---|---|
| XLogP3 | 8.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 10 |
| Exact Mass | 693.27899640 g/mol |
| Monoisotopic Mass | 693.27899640 g/mol |
| Topological Polar Surface Area | 61.4 Ų |
| Heavy Atom Count | 50 |
| Formal Charge | 0 |
| Complexity | 1110 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Lomitapide is a member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. It has a role as an anticholesteremic drug and a MTP inhibitor. It is a member of piperidines, a member of fluorenes, a member of benzamides and a member of (trifluoromethyl)benzenes. It is a conjugate base of a lomitapide(1+).