CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
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Melting Point | >276°C (Ziprasidone Hydrochloride Monohydrate) |
Flash Point | -2 °C (28 °F) - closed cup |
Solubility | 7.18e-03 g/L |
LogP | 3.8 |
Stability/Shelf Life | Stable under recommended storage conditions. |
Collision Cross Section | 192.6 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)] |
Other Experimental Properties | White to slightly pink powder. MW: 467.41. Also prepared as the hemihydrate, mp >300 °C /Ziprasidone hydrochloride monohydrate/ |
SAFETY INFORMATION
Signal word | Warning |
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Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. |
COMPUTED DESCRIPTORS
Molecular Weight | 412.9 g/mol |
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XLogP3 | 4 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 5 |
Rotatable Bond Count | 4 |
Exact Mass | 412.1124602 g/mol |
Monoisotopic Mass | 412.1124602 g/mol |
Topological Polar Surface Area | 76.7 Ų |
Heavy Atom Count | 28 |
Formal Charge | 0 |
Complexity | 573 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. It has a role as a psychotropic drug, a histamine antagonist, a muscarinic antagonist, a serotonergic antagonist, a dopaminergic antagonist and an antipsychotic agent. It is a member of piperazines, an organochlorine compound, a member of indolones and a 1,2-benzisothiazole.