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1420477-60-6

1420477-60-6 structural image
Product Name: Acalabrutinib
Formula: C26H23N7O2
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CHEMICAL AND PHYSICAL PROPERTIES

Solubility Freely soluble in water at pH values below 3 but is practically insoluble in water at pH values above 6
LogP 0.49

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

COMPUTED DESCRIPTORS

Molecular Weight 465.5 g/mol
XLogP3 3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 4
Exact Mass 465.19132300 g/mol
Monoisotopic Mass 465.19132300 g/mol
Topological Polar Surface Area 119 Ų
Heavy Atom Count 35
Formal Charge 0
Complexity 845
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Acalabrutinib is a member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazine substituted by 4-(pyridin-2-ylcarbamoyl)phenyl, (2S)-1-(but-2-ynoyl)pyrrolidin-2-yl, and amino groups at positions 1, 3 and 8, respectively. It is an irreversible second-generation Bruton's tyrosine kinase (BTK) inhibitor that is approved by the FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a member of pyridines, an aromatic amine, a pyrrolidinecarboxamide, an imidazopyrazine, a ynone and a tertiary carboxamide.

RELATED SUPPLIERS

AVD pharmaceuticals Pvt Ltd

2Y
product:1420477-60-6 Acalabrutinib 98%

Svak Life Sciences

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product:1420477-60-6 98%

Salvavidas Pharmaceutical Pvt., Ltd.

1Y
product:Acalabrutinib 98%

Vijaya Pharma And Life Science

1Y
product:Acalabrutinib 1420477-60-6 98%
All suppliers(4)