| Physical Description |
Tan to brown solid; [HSDB] |
| Solubility |
White solid; solubility in water: greater than 100 mg/mL; moderately soluble in methanol; insoluble in higher alcohols, acetone, ether; UV max absorption (water): 282 nm (e = 40, 1%, 1 cm) /Vancomycin hydrochloride/ |
| LogP |
-3.1 |
| Stability/Shelf Life |
When reconstituted with sterile water for injection, vancomycin hydrochloride injection is stable for 2 weeks at room temperature; the manufacturers state that reconstituted injections may be stored for 96 hours at 2 - 8 °C without substantial loss of potency. When reconstituted as directed in 0.9% sodium chloride injection or 5% dextrose injection, solutions prepared from ADD-Vantage vials of the drug are stable for 24 hours at room temperature. Vancomycin solutions containing 5 mg/mL in 0.9% sodium chloride injection or 5% dextrose injection are reportedly stable for at least 17 days when stored at 24 °C in glass or PVC containers and for at least 63 days when stored at 5 °C or -10 °C in glass containers. Following reconstitution with sterile water for injection as directed, vancomycin solutions that have been further diluted to a concentration of 5 mg/mL in 5 - 30% dextrose injection are stable when stored in plastic syringes for 24 hours at 4 eg C and then subsequently for 2 hours at room temperature. |
| Decomposition |
When heated to decomposition, it emits toxic fumes of /nitric oxide/ and /chlorine/. |
| Dissociation Constants |
2.66 |
| Other Experimental Properties |
Tan to brown powder; odorless; bitter taste. Soluble in water; moderately soluble in dilute methanol; insoluble in higher alcohols, acetone, ether /Vancomycin hydrochloride/ |
| Chemical Classes |
Other Uses -> Pharmaceuticals |
