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134404-52-7

134404-52-7 structural image
Product Name: Seocalcitol
Formula: C30H46O3
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COMPUTED DESCRIPTORS

Molecular Weight 454.7 g/mol
XLogP3 5.8
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 7
Exact Mass 454.34469533 g/mol
Monoisotopic Mass 454.34469533 g/mol
Topological Polar Surface Area 60.7 Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 812
Isotope Atom Count 0
Defined Atom Stereocenter Count 6
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 4
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Seocalcitol is a vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.