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129-03-3

129-03-3 structural image
Product Name: Cyproheptadine
Formula: C21H21N
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Color/Form CRYSTALS FROM DIL ETHANOL
Melting Point 112.3-113.3
Solubility WHITE TO SLIGHTLY YELLOW, CRYSTALLINE POWDER; ODORLESS; SLIGHT BITTER TASTE; NONHYGROSCOPIC; 1 G SOL IN 1.5 ML METHANOL, 16 ML CHLOROFORM, 35 ML ALCOHOL, 275 ML WATER; PRACTICALLY INSOL IN ETHER /HCL/
LogP 4.69
Stability/Shelf Life RELATIVELY STABLE IN LIGHT, STABLE @ ROOM TEMP. /HCL/
Kovats Retention Index 2333 2355 2340 2356 2400 2348.4 2360.4 2366 2355 2360 2366 2382
Other Experimental Properties CRYSTALS FROM ABSOLUTE ETHANOL + ETHER. UV MAX (0.1 N H2SO4): 224,285 NM (E AT 1 CM AND 1%= 1,656,355) /HCL/

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

COMPUTED DESCRIPTORS

Molecular Weight 287.4 g/mol
XLogP3 4.7
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 1
Rotatable Bond Count 0
Exact Mass 287.167399674 g/mol
Monoisotopic Mass 287.167399674 g/mol
Topological Polar Surface Area 3.2 Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 423
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Cyproheptadine is the product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia. It has a role as a H1-receptor antagonist, a serotonergic antagonist, an antipruritic drug, an anti-allergic agent and a gastrointestinal drug. It is a member of piperidines and a tertiary amine.

RELATED SUPPLIERS

Ions Pharma

1Y
product:Cyproheptadine 98%

Ralington Pharma

1Y
product:Cyproheptadine 98%

B. Shah & Sons

Mumbai
product:Cyproheptadine
All suppliers(4)