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112828-00-9

112828-00-9 structural image
Product Name: Calcipotriene
Formula: C27H40O3
Synonyms: (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3ε,24-triol;Calcipotriol
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Solubility 1.35e-02 g/L

COMPUTED DESCRIPTORS

Molecular Weight 412.6 g/mol
XLogP3 4.3
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 5
Exact Mass 412.29774513 g/mol
Monoisotopic Mass 412.29774513 g/mol
Topological Polar Surface Area 60.7 Ų
Heavy Atom Count 30
Formal Charge 0
Complexity 743
Isotope Atom Count 0
Defined Atom Stereocenter Count 7
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 3
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Calcipotriol is a seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. It has a role as a drug allergen and an antipsoriatic. It is a member of cyclopropanes, a secondary alcohol, a triol, a hydroxy seco-steroid and a seco-cholestane.