CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Reddish-yellow solid; [Merck Index] |
|---|---|
| Color/Form | Reddish-yellow powder |
| Melting Point | 115-120 °C |
| Solubility | Poorly soluble in water |
| Henry's Law Constant | MW: 499.6 to 1038; log Kow -1.0 to 3.2; Henry's Law constant: negligible to 2.8X10-23 Pa-L/mol (Polypeptides e.g. avermectin, bacitracin, ivermectin, virginamycin) |
| Other Experimental Properties | Amorphous |
| Chemical Classes | Other Uses -> Pharmaceuticals |
COMPUTED DESCRIPTORS
| Molecular Weight | 1349.5 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 19 |
| Rotatable Bond Count | 7 |
| Exact Mass | 1348.60159125 g/mol |
| Monoisotopic Mass | 1348.60159125 g/mol |
| Topological Polar Surface Area | 364 Ų |
| Heavy Atom Count | 98 |
| Formal Charge | 0 |
| Complexity | 2640 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 10 |
| Defined Bond Stereocenter Count | 3 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Virginiamycin is a class of streptogramin-related depsipeptides isolated from the bacterium Streptomyces virginiae and other Streptomyces bacterial species. The virginiamycins consist of two major components, virginiamycin M1 and virginiamycin S1. These agents bind to and inhibit ribosome assembly, thereby preventing protein synthesis. Active against Gram-positive bacteria, these antibiotics are primarily used in veterinary practice. (NCI04)