11002-13-4
Product Name:
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN
Formula:
C83H122N24O19
Synonyms:
Hypertensinogen;Renin substrate
Inquiry
COMPUTED DESCRIPTORS
| Molecular Weight | 1645.9 g/mol |
|---|---|
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 21 |
| Hydrogen Bond Acceptor Count | 22 |
| Rotatable Bond Count | 49 |
| Exact Mass | 1644.88888032 g/mol |
| Monoisotopic Mass | 1644.88888032 g/mol |
| Topological Polar Surface Area | 609 Ų |
| Heavy Atom Count | 118 |
| Formal Charge | 0 |
| Complexity | 3360 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 15 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.