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102203-18-9

102203-18-9 structural image
Product Name: IMETIT DIHYDROBROMIDE
Formula: C6H10N4S
Synonyms: S-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
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COMPUTED DESCRIPTORS

Molecular Weight 170.24 g/mol
XLogP3 0.2
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 4
Exact Mass 170.06261751 g/mol
Monoisotopic Mass 170.06261751 g/mol
Topological Polar Surface Area 104 Ų
Heavy Atom Count 11
Formal Charge 0
Complexity 139
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Imetit is an imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration. It has a role as a H3-receptor agonist and a H4-receptor agonist. It is a member of imidazoles and an imidothiocarbamic ester. It is a conjugate base of an imetit(2+).