AZD3759 ,1626387-80-1

Price	USD50.00
Packge	1KG

Min. Order:1KG
Supply Ability:20ton
Time:2021-08-07

Product Details

Product NameAZD3759
CAS No.1626387-80-1
EINECS No.1592732-453-0
MFC22H23ClFN5O3
MW459.9
Appearancesolid
Boiling point 571.4±50.0 °C(Predicted)
density 1.358±0.06 g/cm3(Predicted)

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Product Name:	AZD 3759
Synonyms:	AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-;1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-[(3-CHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXY-6-QUINAZOLINYL ESTER
CAS:	1626387-80-1
MF:	C22H23ClFN5O3
MW:	459.9
EINECS:	1592732-453-0
Product Categories:	API
Mol File:	1626387-80-1.mol

AZD 3759 Chemical PropertiesBoiling point 571.4±50.0 °C(Predicted)density 1.358±0.06 g/cm3(Predicted)pka6.71±0.40(Predicted)

Safety Information

MSDS Information

AZD 3759 Usage And SynthesisSelective EGFR inhibitor

AZD3759 is a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue. Treatment with AZD3759 causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.

DescriptionAZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system

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Company Profile Introduction

Export of goods or technology, needle textiles, plastic products, rubber products, hardware products, security equipment sales

Shijiazhuang Tongyang Import and Export Co., LTD

Hebei China

Since:2015-05-06
Address: room 1916,haiyuetiandi,66 yuehua west road,xiaoxi district

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