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98048-97-6

98048-97-6 structural image
Product Name: Fosinopril
Formula: C30H46NO7P
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 149 - 153 °C
Solubility 1.01e-03 g/L
LogP 6.3

COMPUTED DESCRIPTORS

Molecular Weight 563.7 g/mol
XLogP3 6.2
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 15
Exact Mass 563.30118980 g/mol
Monoisotopic Mass 563.30118980 g/mol
Topological Polar Surface Area 110 Ų
Heavy Atom Count 39
Formal Charge 0
Complexity 850
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 2
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Fosinopril is a phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a phosphinic ester and a L-proline derivative. It is functionally related to a fosinoprilat. It is a conjugate acid of a fosinopril(1-).