637-07-0
Product Name:
Clofibrate
Formula:
C12H15ClO3
Synonyms:
2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester;Ethyl 2-(4-chlorophenoxy)-2-methylpropionate;Ethyl 2-(4-chlorophenoxy)isobutyrate
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
---|---|
Color/Form | OIL |
Odor | FAINT CHARACTERISTIC ODOR |
Taste | FAINT CHARACTERISTIC TASTE |
Boiling Point | 149 °C at 2.00E+01 mm Hg |
Melting Point | 118-119 |
Solubility | Insoluble |
Density | 1.138-1.144 @ 20 °C |
LogP | 3.3 |
Stability/Shelf Life | SENSITIVE TO OXIDATION AND LIGHT; EASILY HYDROLYZED |
Refractive Index | INDEX OF REFRACTION: 1.500-1.505 @ 19.5-20.5 °C/D; MAX ABSORPTION (DEHYDRATED ETHANOL): 226 NM (A= 910, 1%, 1 CM); 280 NM (A= 87, 1%, 1 CM); 288 NM (A= 62, 1%, 1 CM) |
Kovats Retention Index | 1535.1 1524 1549 1515 1549 |
SAFETY INFORMATION
Signal word | Danger |
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Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
Molecular Weight | 242.70 g/mol |
---|---|
XLogP3 | 3.3 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 5 |
Exact Mass | 242.0709720 g/mol |
Monoisotopic Mass | 242.0709720 g/mol |
Topological Polar Surface Area | 35.5 Ų |
Heavy Atom Count | 16 |
Formal Charge | 0 |
Complexity | 232 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Clofibrate is the ethyl ester of clofibric acid. It has a role as an anticholesteremic drug, an antilipemic drug, a geroprotector and a PPARalpha agonist. It is an aromatic ether, a member of monochlorobenzenes and an ethyl ester. It is functionally related to a clofibric acid.