55096-26-9
Product Name:
Nalmefene
Formula:
C21H25NO3
Synonyms:
(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
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CHEMICAL AND PHYSICAL PROPERTIES
Color/Form | Crystals from ethyl acetate |
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Melting Point | 105-110 °C |
Stability/Shelf Life | Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. |
Dissociation Constants | 7.6 |
Other Experimental Properties | MW: 375.9. White to off-white crystalline powder ... freely soluble in water up to 130 mg/L and slightly soluble in chloroform up to 0.13 mg/mL ... no longer available in the US /Revex/ |
SAFETY INFORMATION
Signal word | Warning |
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Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
COMPUTED DESCRIPTORS
Molecular Weight | 339.4 g/mol |
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XLogP3 | 2.7 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 4 |
Rotatable Bond Count | 2 |
Exact Mass | 339.18344366 g/mol |
Monoisotopic Mass | 339.18344366 g/mol |
Topological Polar Surface Area | 52.9 Ų |
Heavy Atom Count | 25 |
Formal Charge | 0 |
Complexity | 618 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 4 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Nalmefene is a morphinane alkaloid.