CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Dull solid that turns brownish on exposure to light; [Merck Index] Powder; [Alfa Aesar MSDS] |
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Collision Cross Section | 176 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
Chemical Classes | Other Uses -> Food Additives |
COMPUTED DESCRIPTORS
Molecular Weight | 422.5 g/mol |
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Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 8 |
Rotatable Bond Count | 4 |
Exact Mass | 422.15115773 g/mol |
Monoisotopic Mass | 422.15115773 g/mol |
Topological Polar Surface Area | 129 Ų |
Heavy Atom Count | 29 |
Formal Charge | 0 |
Complexity | 538 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 4 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 2 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Quinine Sulfate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)