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53179-11-6

53179-11-6 structural image
Product Name: Loperamide
Formula: C29H33ClN2O2
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Melting Point 220-228
LogP 5.13
Ionization Efficiency Positive
Collision Cross Section 222.7 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Other Experimental Properties Crystals from isopropanol. MP: 222-223 °C. UV Max (0.1N HCl.2-propanol, 10.90 v/v): 253, 259, 265, 273 nm (epsilon 532, 648, 581, 233). Freely soluble in chloroform; slightly soluble in dilute acids; very slightly soluble in isopropyl alcohol. Solubility (g/100 mL): water (pH 7.1) 0.14; citrate-phosphate (pH 6.1) 0.008; methanol 28.6; ethanol 5.37; 2-propanol 1.11; dichloromethane 35.1; acetone 0.20; ethyl acetate 0.035; diethyl ether <0.001; hexane <0.001; toluene 0.001; N,N-dimethylformamide 10.2; tetrahydrofuran 0.32; 4-methyl-2-pentanone 0.02; propylene glycol 5.64; polyethylene glycol 400 1.40; dimethylsulfoxide 20.5; 2-butanone 0.18. pKa 8.66. Practically insoluble at physiological pH (0.002%). Stable, can be stored for several years under normal conditions; not hygroscopic; not affected by light /Loperamide hydrochloride/

COMPUTED DESCRIPTORS

Molecular Weight 477.0 g/mol
XLogP3 5
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 7
Exact Mass 476.2230560 g/mol
Monoisotopic Mass 476.2230560 g/mol
Topological Polar Surface Area 43.8 Ų
Heavy Atom Count 34
Formal Charge 0
Complexity 623
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Loperamide is a synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease. It has a role as a mu-opioid receptor agonist, an antidiarrhoeal drug and an anticoronaviral agent. It is a member of piperidines, a monocarboxylic acid amide, a member of monochlorobenzenes and a tertiary alcohol. It is a conjugate base of a loperamide(1+).

RELATED SUPPLIERS

KARPSCHEM LABORATORIES PVT. LTD.

1Y
product:53179-11-6 Loperamide 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl- 2,2-diphenylbutanamide 96%

Chempro Pharma Pvt Ltd

1Y
product:53179-11-6 99%

VIVAN Life Sciences Pvt Ltd

1Y
product:Loperamide 98%
All suppliers(3)