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53123-88-9

53123-88-9 structural image
Product Name: Rapamycin
Formula: C51H79NO13
Synonyms: Rapamycin;Sirolimus;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution;mTOR Inhibitor I
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Colorless solid; [Merck Index]
Color/Form Colorless crystalline solid from ether
Boiling Point 183-185
Melting Point 183-185 °C
Solubility Sol in ether, chloroform, acetone, methanol, and DMF; very sparingly sol in hexane and petr ether.
LogP 4.63
Optical Rotation Specific optical rotation at 25 °C for D (sodium) line = -58.2 deg (methanol)
Collision Cross Section 311.6 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Other Experimental Properties Hydroxyl radical reaction rate constant = 4.63X10-10 cu-cm/molecule sec at 25 °C /Estimated/
Chemical Classes Biological Agents -> Bacterial Toxins

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.
P501:Dispose of contents/container to..…

COMPUTED DESCRIPTORS

Molecular Weight 914.2 g/mol
XLogP3 6
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 13
Rotatable Bond Count 6
Exact Mass 913.55514157 g/mol
Monoisotopic Mass 913.55514157 g/mol
Topological Polar Surface Area 195 Ų
Heavy Atom Count 65
Formal Charge 0
Complexity 1760
Isotope Atom Count 0
Defined Atom Stereocenter Count 15
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 4
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

Description

Sirolimus is a macrolide lactam isolated from *Streptomyces hygroscopicus*, characterized by a 29-membered ring containing four trans double bonds, three of which are conjugated. This compound functions as an antibiotic, immunosuppressive, and antineoplastic agent. It has multiple roles, including serving as an immunosuppressive agent, an antineoplastic agent, an antibacterial drug, an mTOR inhibitor, a bacterial metabolite, an anticoronaviral agent, and a geroprotector. Structurally, sirolimus is a cyclic acetal, a cyclic ketone, an ether, a secondary alcohol, an organic heterotricyclic compound, an antibiotic antifungal drug, and a macrolide lactam.

RELATED SUPPLIERS

Concord Biotech Limited

1Y
product:53123-88-9 Rapamycin 98%

Allmpus Laboratories Pvt Ltd

1Y
product:53123-88-9 EVEROLIMUS IMPURITY A/SIROLIMUS IMPURITY 95.34
All suppliers(3)