112828-00-9
Product Name:
Calcipotriene
Formula:
C27H40O3
Synonyms:
(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3ε,24-triol;Calcipotriol
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
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Solubility | 1.35e-02 g/L |
COMPUTED DESCRIPTORS
Molecular Weight | 412.6 g/mol |
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XLogP3 | 4.3 |
Hydrogen Bond Donor Count | 3 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 5 |
Exact Mass | 412.29774513 g/mol |
Monoisotopic Mass | 412.29774513 g/mol |
Topological Polar Surface Area | 60.7 Ų |
Heavy Atom Count | 30 |
Formal Charge | 0 |
Complexity | 743 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 7 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 3 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Calcipotriol is a seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. It has a role as a drug allergen and an antipsoriatic. It is a member of cyclopropanes, a secondary alcohol, a triol, a hydroxy seco-steroid and a seco-cholestane.