Trifluoroacetic acid
Synonym(s):TFA;TFA in H2O/ACN;TFA solution;Trifluoroacetic acid solution;Trifluoroacetic acid ZerO2
- CAS NO.:76-05-1
- Empirical Formula: C2HF3O2
- Molecular Weight: 114.02
- MDL number: MFCD00004169
- EINECS: 200-929-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-07 17:43:10
What is Trifluoroacetic acid?
Description
Trifluoroacetic acid (TFA) is a strong organic acid typically used as a solvent or acid catalyst. TFA is the CF3 analogue of acetic acid (AcOH) which due to the electron withdrawing effect of the fluorine atoms is much more acidic than AcOH. The pKa of TFA is 0.23, compared to a pKa of 4.76 for AcOH. The low boiling point (bp = 72 C) of TFA facilitates simpler product isolation due to the fact that it can be removed via concentration on rotovap.
The Uses of Trifluoroacetic acid
Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid can use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry. It is used as a catalyst in esterification reaction and condensation reaction and a protective agent for hydroxyl and amino.
What are the applications of Application
Trifluoroacetic acid is a strong non-oxidizing acid
Properties of Trifluoroacetic acid
Melting point: | -15.4 °C (lit.) |
Boiling point: | 72.4 °C (lit.) |
Density | 1.489 g/mL at 20 °C (lit.) |
Flash point: | None |
storage temp. | Store at +15°C to +25°C. |
solubility | Miscible with ether, acetone, ethanol, benzene, hexane, and CCl<sub>4</sub> |
form | Liquid |
appearance | Colorless liquid |
color | Colorless |
Odor | Sharp, pungent odor |
Water Solubility | miscible |
Sensitive | Hygroscopic |
Safety information for Trifluoroacetic acid
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H314:Skin corrosion/irritation H332:Acute toxicity,inhalation H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Trifluoroacetic acid
InChIKey | DTQVDTLACAAQTR-UHFFFAOYSA-N |
Abamectin manufacturer
SUJALAM CHEMICALS
JSK Chemicals
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