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HomeProduct name listTrichloroacetic acid

Trichloroacetic acid

Synonym(s):TCA;Trichloroacetic acid;Trichloroacetic Acid - CAS 76-03-9 - Calbiochem

  • CAS NO.:76-03-9
  • Empirical Formula: C2HCl3O2
  • Molecular Weight: 163.39
  • MDL number: MFCD00004177
  • EINECS: 200-927-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-11-28 16:31:44
Trichloroacetic acid Structural Picture

What is Trichloroacetic acid?

The Uses of Trichloroacetic acid

Protein precipitation reagentTrichloroacetic acid is used as a precipitating agent in biochemistry for precipitation of proteins, DNA and RNA. It is an active ingredient used in cosmetic treatments like chemical peels, tattoo removal and the treatment of warts including genital warts. It is also used to determine protein concentration and as a decalcifier and fixative in microscopy.

Background

Trichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. In clinical chemistry and biochemistry, it is used as a precipitant of macromolecules including proteins, DNA and RNA. Trichloroacetate is also found in cosmetic treatments and topical formulations as a cauterant, which removes condyloma or warts on the skin.

What are the applications of Application

Trichloroacetic acid is an acetic acid analogue commonly used to precipitate proteins, DNA and RNA

Metabolism

Not Available

Properties of Trichloroacetic acid

Melting point: 54-58 °C (lit.)
Boiling point: 196 °C (lit.)
Density  1.62 g/mL at 25 °C (lit.)
Flash point: 196°C
storage temp.  Store at +15°C to +25°C.
solubility  H2O: 0.5 M at 20 °C, clear, colorless
form  Solid
color  White
Water Solubility  120 g/100 mL (20 ºC)
Sensitive  Hygroscopic

Safety information for Trichloroacetic acid

Signal word Danger
Pictogram(s)

Corrosion
Corrosives
GHS05

Exclamation Mark
Irritant
GHS07

Environment
GHS09
GHS Hazard Statements H314:Skin corrosion/irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Trichloroacetic acid

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