Tetrabutylammonium fluoride

Synonym(s):‘Fluoride’ on silica gel;TBAF;TBAF on silica gel;TBAF solution

CAS NO.：429-41-4
Empirical Formula: C16H36FN
Molecular Weight: 261.46
MDL number: MFCD00149980
EINECS: 207-057-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-16 17:35:26

Tetrabutylammonium fluoride Structural Picture

What is Tetrabutylammonium fluoride?

Description

TBAF is typically obtained as a trihydrate (TBAF-3H2O), 1M solution in THF, or 75 wt% solution in H2O. TBAF will always contain some water due to the fact that the fluorine ion is such a great hydrogen bond acceptor.

The Uses of Tetrabutylammonium fluoride

Tetrabutylammonium fluoride is a reagent in organic syntheses in addition, condensation, base-catalyzed cyclization reactions, fluorination and desulfonylation reactions and as a deprotecting agent. Typically dried prior to use.

The Uses of Tetrabutylammonium fluoride

Tetrabutylammonium fluoride
To a stirred solution of the SM (250 mg, 0.43 mmol) in THF (4 mL) was added TBAF (4 mL, 1M in THF). The reaction mixture was stirred at 80 C for 12 h. After cooling to RT, the mixture was diluted with EtOAc (20 mL), washed with H2O, and concentrated in vacuo. The crude material was purified by Prep HPLC (formic acid) to provide the product as a white solid. [24 mg, 12%]

What are the applications of Application

Tetrabutylammonium Fluoride is a reactant used for the synthesis of multiple compounds

Properties of Tetrabutylammonium fluoride

Melting point:	62-63 °C(lit.)
Density	0.953 g/mL at 25 °C
Flash point:	1 °F
storage temp.	2-8°C
solubility	Miscible with terahydrofuran, acetonitrile, dimethyl sulfoxide and organic solvents.
form	Solution
color	Clear light greenish to brown
Water Solubility	Insoluble in water.
Sensitive	Hygroscopic

Safety information for Tetrabutylammonium fluoride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.