tert-Butyldimethylsilyl chloride
Synonym(s):TBDMSCl;tert-Butyldimethylchlorosilane;tert-Butyldimethylsilyl chloride, tert-Butylchlorodimethylsilane, TBDMSCl;TBDMSCl solution;tert-Butyl(chloro)dimethylsilane
- CAS NO.:18162-48-6
- Empirical Formula: C6H15ClSi
- Molecular Weight: 150.72
- MDL number: MFCD00000501
- EINECS: 242-042-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-03 14:46:32
What is tert-Butyldimethylsilyl chloride?
Description
tert-Butyldimethylsilyl chloride (TBS-Cl) is generally used as a reagent for installing TBS protecting groups. A similar reagent is tert-butyldimethylsilyl trifluoromethanesulfonate (TBS-OTf).
The Uses of tert-Butyldimethylsilyl chloride
tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols.
The Uses of tert-Butyldimethylsilyl chloride
To a solution of the SM (985 mg, 5.24 mmol), imidazole (371 mg, 5.30 mmol), and DMF (5 mL) was added portionwise TBSCl (814 mg, 5.24 mmol). The reaction mixture was stirred at RT for 4 h. The mixture was concentrated in vacuo, diluted with H2O, and extracted with EtOAc (3x). The combined organics were washed with brine, dried (MgSO4), and concentrated to provide the product as an orange oil which was used without further purification. [1.43 g, 90%]
What are the applications of Application
tert-Butylchlorodimethylsilane solution is Used to protect alcohols during organic synthesis.
Properties of tert-Butyldimethylsilyl chloride
Melting point: | 86-89 °C (lit.) |
Boiling point: | 125 °C (lit.) |
Density | 0.87 g/mL at 20 °C(lit.) |
Flash point: | 73 °F |
storage temp. | Store below +30°C. |
solubility | very sol nearly all common organic solvents such as
THF, methylene chloride, and DMF. |
form | white solid |
color | white |
Water Solubility | Soluble in chloroform and ethyl acetate. Insoluble in water. |
Sensitive | Moisture Sensitive |
Safety information for tert-Butyldimethylsilyl chloride
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H225:Flammable liquids H304:Aspiration hazard H314:Skin corrosion/irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H373:Specific target organ toxicity, repeated exposure H411:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for tert-Butyldimethylsilyl chloride
InChIKey | BCNZYOJHNLTNEZ-UHFFFAOYSA-N |
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