tert-Butyl methyl ether

The Uses of tert-Butyl methyl ether

Methyl tert-butyl ether (MTBE) was primarily used as a gasoline additive in unleaded gasoline in the United States prior to 2005, in the manufacture of isobutene, and as a chromatographic eluent especially in high pressure liquid chromatography. It is also a pharmaceutical agent and can be injected into the gallbladder to dissolve gallstones (ATSDR, 1996). tert-Butyl methyl ether is also used in the petrochemical industry. By reversal of its formation reaction, MTBE can be cracked to isobutene and methanol on acidic catalysts at higher temperature than MTBE synthesis.

The Uses of tert-Butyl methyl ether

To a suspension of the amine (3.0 g, 11.4 mmol), the acid (2.88 g, 9.54 mmol), and TEA (4.81 mL, 34.5 mmol) in DMSO (30 mL) was added HBTU (4.34 g, 34.5 mmol). The reaction mixture was stirred at RT for 18 h, after which time it was diluted with EtOAc (100 mL), washed with H2O (100 mL), brine (3 x 100 mL), dried (Na2SO4), and concentrated to a brown solid. The resulting material was triturated in MTBE then EtOAc to provide the product. [3.97 g, 7.8 mmol]

What are the applications of Application

tert-Butyl methyl ether is a reagent for the oxygenation of fuels